Cathelicidin OA-1 is an amphibian peptide, specifically found in the odorous frog O. andersonii species, that exhibits rapid acceleration of wound healing. The properties of exponential growth exhibited in these frogs are necessary due to the extremely harsh environments they inhabit. This study aims to examine the use of Cathelicidin-OA1 on human epithelial cells during wound healing simulations. Prior studies have shown that the Cathelicidin-OA1 peptide has accelerated full-thickness dermal wound healing in murine models, thus expediting the formation of epithelial and granulation tissue of the wound site using macrophages. This research will use a method of cell migration utilizing five different treatments conditions on epithelial cells in vitro cell scratch assay to achieve a deeper investigation of the healing properties of this peptide. This study may develop further understanding of the Cathelicidin-OA1 peptide at the cellular level and promote the use of these properties to produce new cell therapies for wound healing for humans.  The discovery of a positive effect from the Cathelicidin-OA1 peptide on epithelial cells that could result in new wound therapy would consequently benefit the patients. Not only would hospitals be able to maintain high standards of care due to more effective and efficient treatment options, but also patients may have a decreased length of hospital visits and hospital costs due to the acceleration of wound healing. 

**Keywords: Amphibian, Cathelicidin-OA1,  Wound Healing