Both antibiotic and antioxidant properties are vital in the scope of medical research. Studies of the antioxidant and antibiotic properties of these eugenol derivatives are important for addressing pressing global health challenges, such as antibiotic resistance and oxidative stress-related diseases. We looked at a green alternative for synthesizing the epoxide derivatives of eugenol using oxone and compared yields to those obtained using more harmful alternatives. We found increased yields when using acetyl eugenol and allyl anisole as substrates. These results suggest that the oxidation reaction is more effective in the absence of the phenol functional group. After all derivatives were synthesized and purified, their bioactivities were investigated, to determine which derivatives could possibly show either antioxidant or antibiotic properties.