Nano-hydroxyapatite is becoming an increasingly popular ingredient in fluoride-free oral

hygiene products. The intent of this research is to settle the debate: Which product yields more

effective results in the overall fight for remineralization? Our research uses quantitative studies

found in scholarly, peer-reviewed articles. A trendy subject for those interested in a more holistic

lifestyle, nano-hydroxyapatite is a biocompatible, biomimetic agent. It is a nanoscopic synthetic

derivative from hydroxyapatite, which is a naturally occurring mineral found in bones and teeth.

Since nano-hydroxyapatite is still relatively new to the dental market, the overall efficacy is

currently under discussion. Fluoride is the current gold standard for remineralization that has

been researched and supported by dental professionals for decades. When comparing the two,

nano-hydroxyapatite has not yet been seen as an equal. The articles we reviewed used in vitro,

single-blind, and double-blind methods to accumulate effective research. Each study used a

controlled amount of demineralized enamel as the subject, and separately applied nano-

hydroxyapatite and fluoride products directly onto the enamel. These studies then compared the

extent of remineralization after a prolonged time, ranging from immediate results to 6

months. Three studies demonstrated that fluoride had a significantly greater outcome in its

effectiveness than nano-hydroxyapatite. In contrast, the results of three different studies that

compared similar products showed that nano-hydroxyapatite was the superior out of the two. A

final study was reviewed showing that there was no significant contrast in comparison of the two

seemingly equal products, reinforcing the tie. With this insightful information, we have

concluded that nano-hydroxyapatite and fluoride are equally as effective in the process of

remineralization. With a promising future, nano-hydroxyapatite proves itself as a strong

contender within the scope of dentistry.