This paper examines the life of Henry VI of England (1421-1471) who suffered from catatonic schizophrenia, which is diagnosed by medical experts in a modern medical analysis of symptoms noted during his lifetime, and analyzes its impact on the political and religious life of fifteenth-century England. The life of Henry VI was filled with turmoil and instability. His reign saw defeat in France at the end of the Hundred Years' War, and the beginning of a civil war in England known as the "Wars of the Roses." Henry suffered from a mental disability that contributed to the ineffective leadership he displayed, allowing rivals to seize power from him.  Henry's physical and mental state was devastated by his battle with catatonic schizophrenia which forced him to be absent from the throne. As a result, this created a power vacuum within the kingdom and allowed many of his political rivals, such as Richard the Duke of York, to take advantage of Henry’s suffering seize control of the kingdom, and start a civil war. Henry’s disability drastically affected not only the political history of early modern England but its religious history as well;  Henry became the subject of a religious cult after his death and was said to work miracles for believers.