Multiple Sclerosis (MS) is a chronic neurodegenerative disorder of the central nervous system characterized by inflammatory demyelination and progressive neurological disability. Current clinical assessments of MS-related disability are often impractical due to their complexity and time-intensive requirement. Grip strength, as measured using a dynamometer, is a quick, simple, and sensitive measure of muscle weakness, a common symptom in MS. However, few studies have examined its clinical utility. This single-center cross-sectional study examines the extent to which grip strength correlates with standard objective and patient-reported measures of MS disability, and tests whether greater discrepancies between dominant and non-dominant hand grip strength are associated with greater MS disability burden. 516 MS patients completed grip strength testing of dominant and non-dominant hands and standard MS disability measures, including objective measures [eg, Expanded Disability Status Scale (EDSS), Age-Related MS Severity (ARMSS), Timed 25-Foot Walk (T25W), 9-Hole Peg Test (9-HPT), Symbol Digit Modality Test (SDMT)] and patient-reported outcomes [eg, Patient-Determined Disease Steps (PDDS), Multiple Sclerosis-Related Scale-Revised (MSRS-R)]. Multivariate regression models assessed grip strength and inter-hand discrepancies in relation to standard MS disability measures, adjusting for demographic and clinical confounders such as age, gender, race/ethnicity, MS subtype, disease duration and disease-modifying therapy. Dominant and non-dominant grip strength significantly correlated with 9-HPT, T25W, EDSS, and MSRS-R, while differences between dominant and non-dominant grip strength significantly correlated with PDDS, EDSS, and MSRS-R. Notably, reduced dominant grip strength (estimate = -0.021, p<0.05, 95% CI = [-0.040, -0.003]) and greater inter-hand discrepancies (estimate = 0.0458, p<0.001, 95% CI = [0.021, 0.072]) significantly correlated with patient-reported MS disability severity (as measured by PDDS). These findings highlight grip strength testing as a practical measure of MS disability progression, with potential for broader clinical application. Further validation is warranted to confirm its clinical utility.