In science and mathematics, interconnectedness has been evident throughout history. Sir Isaac Newton was heavily influenced by Ancient Greek mathematicians and philosophers (namely Archimedes, Eudoxus, and Pythagoras, among several others) in the same way William Herschel, Michael Faraday, and Albert Einstein’s contributions to STEM were all shaped by Newton. This sharedness among the pioneers of STEM shows how theorems, concepts, and disciplines start with one mind and then continually evolve to become a body of foundations as time progresses. The irony is that while he had a group of influences, Newton’s solitude played a significant role in the conception of calculus. Newton first devised theories of calculus as a student at Cambridge, where he largely kept to himself and had minimal social interactions. Later, he would finalize the foundational concepts of calculus during the Great Plague of London, where he quarantined and isolated himself in his family home, Woolsthorpe. Derivatives, definite and indefinite integrals, rates of change, infinite series, and many more were the outcomes of the years he spent alone, a testament to the power of individual creativity. Despite Newton working alone when developing calculus concepts, Gottfried Wilhelm Leibniz was actually on the other side of Europe publishing his version of calculus. Although friendship and collaboration would have been expected between similar minds, there was a rivalry and dispute regarding credits instead. This shows how Newton’s upbringing and personal struggles drove him to shut himself off from potential companionships. Ultimately, Sir Isaac Newton proves that even in solitude, a single mind can shape the foundations of human knowledge and inspire future generations.