The concept of “saint” exists in many cultures globally, but under this blanket term, the portrayer of saints is culturally specific. This cultural specificity is demonstrated through the comparison of two sculptures: Saint Clement Seated, by the Abruzzi School, made in Sicily, Italy in the 12th century, and Saint Sambandar, created in South India during the Chola Period, also in the 12th century.  The former is a saint of Sicilian Catholicism compared, while the latter reflects South Indian Hinduism. The comparative examination is supported by historical articles written by scholars on the context and events of both 12th-century Sicily and South India. First, I will provide a comparison of the defined meaning of saint within the two cultures. Second, the notion of Saint Clement Seated in Catholic Italy will be discussed, considering formal analysis within a historical framework, followed by a formal and historical analysis of Saint Sambandar. The comparative conclusion will establish the similarities and differences between the expectations, appearances, and behaviors of the two saints, emphasizing a higher value placed on dynamic motion, and bodily autonomy in Hindu saints. At the same time, stoicism, modesty, and minimal attention to the human figure characterized Catholic Sicily. Despite the contrasting elements, comparatively, both pieces reflect an emphasis on poignant facial features, detail in drapery, and dynamic hand positions relaying a gestural form of nonverbal communication.