Adolescents are susceptible to depression during a critical developmental period, negatively impacting their social relationships. Depression impacts various cultures, including Americans and Chinese immigrant adolescents. A literature review  that examined depressive symptoms from before and after the COVID-19 pandemic reveals that during the pandemic the prevalence of depression in both American and Chinese adolescents significantly increased. Notably, research indicates higher increase in prevalence of depressive symptoms among Chinese adolescents in immigrant families, in comparison with American adolescents, primarily due to acculturation being an added stress. A crucial factor for adolescent mental health is their relationships with their peers. Academic pressure and reduced opportunities for in-person interactions related to the COVID-19 lockdown likely intensified symptoms of depression in adolescents. In contrast, a positive and uplifting environment amongst peers provides support for someone who may be depressed. Future research should focus on developing better social skills and tracking rates of depressive symptoms in adolescents, focusing on acculturation with Chinese immigrant adolescents.